Creatine Kinase (CK)
AKA
- Creatine phosphokinase (CPK)
Overview
Creatine Kinase (CK) is an enzyme
CK functions to catalyze the reaction of creatine and adenosine triphosphate (ATP) to phosphocreatine (PCr) and adenosine diphosphate (ADP)1
Chemical Reaction
CK is used to catalyze the following reversible reaction:
\[ ADP + PCr ⇌ ATP + Cr ΔG′° = −12.5 kJ/mol \]
ATP can be generated from PCr and ADP.
The phosphocreatine (PCr) created from this reaction is used to supply tissues and cells that require substantial amounts of ATP, like the brain, skeletal muscles, and the heart, with their required ATP
Chemical structures
See McLeish (2005) Relating structure to mechanism in creatine kinase2
Elevated CK Blood levels
- Increased by physical activity3
Physical activity
- CK levels transiently rise after exercise or heavy manual labor
- Post-exercise (strenuous physical activity) Serum CK levels increase (up to 30x) within 24 hours and then declines over 7 days3
- Amount of CK increase is dependent upon the type and duration of exercise3
- Untrained individuals experience greater elevation3
Nonneuromuscular causes
Further reading
Journal club
Creatine Kinase-Myocardial Band (#creatine-kinase-mb)
Discussed in the cardiac evaluation
References
1.
Aujla RS, Patel R. Creatine Phosphokinase. In: StatPearls. StatPearls Publishing; 2023. Accessed January 22, 2024. http://www.ncbi.nlm.nih.gov/books/NBK546624/
2.
McLeish MJ, Kenyon GL. Relating structure to mechanism in creatine kinase. Critical Reviews in Biochemistry and Molecular Biology. 2005;40(1):1-20. doi:10.1080/10409230590918577
3.
Moghadam-Kia S, Oddis CV, Aggarwal R. Approach to asymptomatic creatine kinase elevation. Cleveland Clinic Journal of Medicine. 2016;83(1):37-42. doi:10.3949/ccjm.83a.14120
Citation
For attribution, please cite this work as:
Yomogida N, Kerstein C. Creatine Kinase (CK).
https://yomokerst.com/The
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